Scientists Reveal Why Mosquitoes Bite Some People More Than Others - ScienceAlert

Add ScienceAlert on Google (LWA/Getty Images) Ever felt like mosquitoes bite you while ignoring everyone else? Scientists are now making progress in deciphering the complex chemical cocktail that makes particular people more enticing to these disease-spreading bloodsuckers. "It's not a misconception – mosquitoes are attracted to some people more than others," Frederic Simard of France's Institute of Research for Development told AFP. "But we are not all magnets all the time," the medical entomologist added. A range of sensory cues can cause mosquitoes to pick one human over another – mainly the smell and heat our bodies give off, and the carbon dioxide we exhale. Female mosquitoes – which are the only ones that bite – detect these signals with finely-tuned receptors, then choose their target accordingly. "We have known for over 100 years that mosquitoes are attracted by the carbon dioxide that we exhale – this is the first signal that triggers their behavior" when they are dozens of meters away, Swedish scientist Rickard Ignell told AFP. Within around 10 meters, "mosquitoes will start detecting our odor, and in combination with carbon dioxide," this attracts them even more, said the senior author of a recent study on the subject. As they get closer, body temperature and humidity make particular humans even more enticing. However, some popular theories on this subject do not hold water. The idea that mosquitoes prefer particular blood types "has no scientific basis," Simard said. "There have been some studies, but only involving very few people," he said. "Nor is it related to skin, eye or hair color," he added. Odor, on the other hand, matters greatly. "A soup of molecules produced by our microbiota is more – or less – appealing to mosquitoes," Simard explained. Humans release between 300 and 1,000 different odorous compounds, research has shown, but scientists are only just beginning to understand which ones attract mosquitoes. For Ignell's recent study, the researchers released Aedes aegypti mosquitoes – known for spreading yellow fever and dengue – on 42 women in a lab, to see which ones they preferred. "We have shown that mosquitoes use a blend of odorous compounds (we identified 27 that the mosquitoes will detect, out of the possible 1,000) for their attraction to us," Ignell said. The women the mosquitoes most liked to bite – which included pregnant women in their second trimester – produced a large amount of a particular compound made by a breakdown of the skin oil sebum. That even a small increase of this compound – called "1-octen-3-ol", or mushroom alcohol – made a difference came as a surprise, Ignell emphasized. "Mosquitoes are fascinating creatures," he added. Drinking beer has also been linked to attracting mosquitoes, because it raises body temperature, increases the amount of exhaled CO2 and changes skin odor, according to several studies. For standardized research conducted in Burkina Faso, some brave volunteers drank beer, then several days later water, to see which mosquitoes preferred. The Anopheles mosquito, which can spread malaria, was more enticed by the scent of the beer drinkers. For a 2023 study in the Netherlands, 465 volunteers put their arms in cages filled with female Anopheles mosquitoes. The volunteers who had drunk beer in the previous 24 hours were 1.35 times more attractive to the mosquitoes. Discovering why mosquitoes prefer particular people has become a more pressing issue as climate change expands the range where they roam. For example, the tiger mosquito, a vector for the chikungunya virus, is spreading into new areas. Last year, chikungunya reached as far north as France's Alsace region for the first time. "This risk is affecting more and more people," Simard said. Related: Mosquitoes Are Feeding on Us More Often – And Scientists Say We're to Blame So what can you do to avoid getting bitten? Try loose-fitting clothing that covers your skin, mosquito nets and repellent, Simard advised. "Try to eat light meals – and go easy on the alcohol," he added.